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Ober, Carole
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overview The research goals of my laboratory are to identify genetic variants that influence gene expression and epigenetic marks in tissues relevant to complex phenotypes and common diseases, in particular those related to asthma, allergy and preterm birth. To this end we are using both freshly isolated cells and tissues and cell culture models of gene-environment interactions to dissect the genetic architecture of common diseases. Our studies are conducted in founder populations, the Hutterites of South Dakota and the Amish of northern Indiana, in U.S. and European birth cohorts, and in patient populations from Chicago.
One or more keywords matched the following items that are connected to Ober, Carole
Item TypeName
Concept Antigen-Presenting Cells
Concept Antigens, Differentiation
Concept Cell Line, Transformed
Concept Antigens, Differentiation, T-Lymphocyte
Concept Histocompatibility Antigens Class II
Concept Cell Differentiation
Concept Cell Transformation, Viral
Concept Epithelial Cells
Concept Killer Cells, Natural
Concept HLA-DR Antigens
Concept HLA-D Antigens
Concept HLA-DQ Antigens
Concept HLA Antigens
Concept Receptors, Cell Surface
Concept Receptors, Immunologic
Concept HLA-A2 Antigen
Concept Stem Cells
Concept Receptors, IgG
Concept HLA-A Antigens
Concept CD28 Antigens
Concept Histocompatibility Antigens Class I
Concept Tumor Cells, Cultured
Concept Antigens, CD
Concept Prostate-Specific Antigen
Concept Receptors, Tumor Necrosis Factor
Concept Th2 Cells
Concept Genes, T-Cell Receptor
Concept Lipopolysaccharide Receptors
Concept Inducible T-Cell Co-Stimulator Protein
Concept B7-H1 Antigen
Concept Receptors, Odorant
Concept Receptors, Muscarinic
Concept Receptors, KIR2DL5
Concept Receptor, Muscarinic M3
Concept CTLA-4 Antigen
Concept Stromal Cells
Concept CD3 Complex
Concept HLA-G Antigens
Concept Cell Line, Tumor
Concept Cell Line
Concept Cells, Cultured
Concept HLA-B Antigens
Concept Antigens, Dermatophagoides
Concept Scavenger Receptors, Class A
Academic Article Mononuclear-cell immunisation in prevention of recurrent miscarriages: a randomised trial.
Academic Article Transmission disequilibrium of maternally-inherited CTLA-4 microsatellite alleles in idiopathic recurrent miscarriage.
Academic Article HLA-G1 protein expression is not essential for fetal survival.
Academic Article Paternally inherited HLA alleles are associated with women's choice of male odor.
Academic Article A null mutation in HLA-G is not associated with preeclampsia or intrauterine growth retardation.
Academic Article Variation in the HLA-G promoter region influences miscarriage rates.
Academic Article Sequence variation in the promoter region of the cholinergic receptor muscarinic 3 gene and asthma and atopy.
Academic Article Linkage disequilibrium and age estimates of a deletion polymorphism (1597DeltaC) in HLA-G suggest non-neutral evolution.
Academic Article Cutting edge: polymorphisms in the ICOS promoter region are associated with allergic sensitization and Th2 cytokine production.
Academic Article Evidence of balancing selection at the HLA-G promoter region.
Academic Article Does HLA-dependent chimerism underlie the pathogenesis of juvenile dermatomyositis?
Academic Article Effects of dog ownership and genotype on immune development and atopy in infancy.
Academic Article HLA-G and immune tolerance in pregnancy.
Academic Article Allele-specific targeting of microRNAs to HLA-G and risk of asthma.
Academic Article The genetics of asthma and allergic disease: a 21st century perspective.
Academic Article The effects of EBV transformation on gene expression levels and methylation profiles.
Academic Article Genetic analysis of HLA in the U.S. Schmiedenleut Hutterites.
Academic Article Adverse effects of human leukocyte antigen-DR sharing on fertility: a cohort study in a human isolate.
Academic Article The combination of a genome-wide association study of lymphocyte count and analysis of gene expression data reveals novel asthma candidate genes.
Academic Article HLA-DQA1 and HLA-DQB1 haplotypes in aborted fetuses and couples with recurrent spontaneous abortion.
Academic Article MHC class II compatibility in aborted fetuses and term infants of couples with recurrent spontaneous abortion.
Academic Article Sequence variations at the human leukocyte antigen-linked olfactory receptor cluster do not influence female preferences for male odors.
Academic Article Shared HLA antigens and reproductive performance among Hutterites.
Academic Article HLA and mate choice in humans.
Academic Article Fine mapping and positional candidate studies identify HLA-G as an asthma susceptibility gene on chromosome 6p21.
Academic Article Variation in ITGB3 is associated with asthma and sensitization to mold allergen in four populations.
Academic Article Further replication studies of the EVE Consortium meta-analysis identifies 2 asthma risk loci in European Americans.
Academic Article The miscarriage-associated HLA-G -725G allele influences transcription rates in JEG-3 cells.
Academic Article HLA-G genotypes and pregnancy outcome in couples with unexplained recurrent miscarriage.
Academic Article The maternal HLA-G 1597?C null mutation is associated with increased risk of pre-eclampsia and reduced HLA-G expression during pregnancy in African-American women.
Academic Article Maternal asthma and microRNA regulation of soluble HLA-G in the airway.
Academic Article The CTLA-4 gene is expressed in placental fibroblasts.
Academic Article Effect of inbreeding avoidance on Hardy-Weinberg expectations: examples of neutral and selected loci.
Academic Article HLA and pregnancy: the paradox of the fetal allograft.
Academic Article HLA-G polymorphisms: neutral evolution or novel function?
Academic Article Population genetic studies of HLA-E: evidence for selection.
Academic Article Population genetic studies of HLA-G: allele frequencies and linkage disequilibrium with HLA-A1.
Academic Article Human leukocyte antigen matching and fetal loss: results of a 10 year prospective study.
Academic Article The effect of freeze-thaw cycles on gene expression levels in lymphoblastoid cell lines.
Academic Article Host genetic variation influences gene expression response to rhinovirus infection.
Academic Article Genome-Wide Methylation Study Identifies an IL-13-induced Epigenetic Signature in Asthmatic Airways.
Academic Article Expression Quantitative Trait Locus Mapping Studies in Mid-secretory Phase Endometrial Cells Identifies HLA-F and TAP2 as Fecundability-Associated Genes.
Academic Article DNA methylation in lung cells is associated with asthma endotypes and genetic risk.
Grant Prenatal Origins of Asthma
Academic Article Parent of origin gene expression in a founder population identifies two new candidate imprinted genes at known imprinted regions.
Academic Article Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks.
Academic Article Effects of an Fc?RIIA polymorphism on leukocyte gene expression and cytokine responses to anti-CD3 and anti-CD28 antibodies.
Academic Article Associations between fungal and bacterial microbiota of airways and asthma endotypes.
Academic Article T-cell phenotypes are associated with serum IgE levels in Amish and Hutterite children.
Academic Article Advances in asthma and allergic disease genetics: Is bigger always better?
Academic Article Transcriptional programming and T cell receptor repertoires distinguish human lung and lymph node memory T cells.
Academic Article Transcriptional programming and T cell receptor repertoires distinguish human lung and lymph node memory T cells.
Academic Article Club Cell TRPV4 Serves as a Damage Sensor Driving Lung Allergic Inflammation.
Academic Article Association of respiratory allergy, asthma, and expression of the SARS-CoV-2 receptor ACE2.
Academic Article Expression quantitative trait locus fine mapping of the 17q12-21 asthma locus in African American children: a genetic association and gene expression study.
Academic Article Cytokine-induced molecular responses in airway smooth muscle cells inform genome-wide association studies of asthma.
Academic Article Altered transcriptional and chromatin responses to rhinovirus in bronchial epithelial cells from adults with asthma.
Academic Article Transcriptome and regulatory maps of decidua-derived stromal cells inform gene discovery in preterm birth.
Academic Article A-to-I editing of miR-200b-3p in airway cells is associated with moderate-to-severe asthma.
Academic Article Extensive pleiotropism and allelic heterogeneity mediate metabolic effects of IRX3 and IRX5.
Academic Article Establishment of human induced trophoblast stem-like cells from term villous cytotrophoblasts.
Academic Article Multiethnic genome-wide and HLA association study of total serum IgE level.
Academic Article Multi-omics colocalization with genome-wide association studies reveals a context-specific genetic mechanism at a childhood onset asthma risk locus.
Academic Article New Insights Relating Gasdermin B to the Onset of Childhood Asthma.
Academic Article DNA methylation signatures in airway cells from adult children of asthmatic mothers reflect subtypes of severe asthma.
Concept Interleukin-1 Receptor-Like 1 Protein
Grant Airway inflammation and HLA-G in asthma
Grant COLLABORATIVE STUDY OF THE GENETICS OF ASTHMA (CSGA)
Grant Genomic Studies of Sex-Specific Architecture of Asthma-Associated Traits
Grant THERAPIES FOR RECURRENT MISCARRIAGE: A RANDOMIZED STUDY
Academic Article Single cell profiling at the maternal-fetal interface reveals a deficiency of PD-L1+?non-immune cells in human spontaneous preterm labor.
Academic Article Epigenetic responses to rhinovirus exposure in airway epithelial cells are correlated with key transcriptional pathways in chronic rhinosinusitis.
Academic Article Gene-based association study of rare variants in children of diverse ancestries implicates TNFRSF21 in the development of allergic asthma.
Search Criteria
  • Receptor
  • CD3 Complex
  • Antigen T
  • Cell